1. Drilling holes in acrylic successfully is possible but requires you to be very careful.  Here’s how to do it:
  2. If the acrylic panel isn’t covered on the front and back of the target area use masking tape on both sides.
  3. Pick a sharp drill bit.  It doesn’t matter if its for wood or metal.  Keep in mind you’re fairly limited in hole size to under 1/4” or around 6mm.  Anything larger and you’re better off using a laser.
  4. Use a slow speed on the drill bit and push very lightly as you drill.  It should take several minutes to successfully drill through even a thin 3mm sheet.  If you push hard the acrylic will probably crack.